This formula includes the natural active form of folate as [6s]-5-methyltetrahydrofolate. Folate’s inclusion is important because it works synergistically with vitamin B12 in supporting methylation and cell replication, and in helping to promote balanced concentrations of homocysteine.
Conditions Associated with B12 Deficiency
There are many conditions where a B12 deficiency acts as an etiological or aggravating factor. Many of these have been shown to improve with adequate B12 supplementation (very high doses of 0.5-1 mg).
It is often necessary to optimize the status of many other synergistic nutrients in order to support the reversal of these conditions. Folate is one of the most important cofactors that helps realize the benefits of optimizing B12 status.
Other B vitamins, essential minerals, and fatty acids may also have crucial effects in allowing B12 benefits to be maximized, thus the need to supplement with multivitamin, multimineral and essential fatty acid formulas should always be evaluated.
The Lozenge Advantage
Trifolamin™ uses a lozenge delivery system, allowing for two routes of absorption for vitamin B12 and folate.
- Directly through the oral mucosa
- Bound by haptocorrin (binding protein secreted in saliva) and carried to the GI tract
Synergistic Mechanisms of Action of B12 and Folate
- B12 and folate are in high demand by cells with high turnover rate, such as epithelial cells in skin, oral and GI mucosa. B12 and folate are instrumental to new DNA synthesis needed for optimal cell replication and differentiation. Pregnancy is an especially demanding condition where healthy cell division and differentiation is needed for adequate fetal development.
- B12 supports energy production from branched chain amino acids, odd-chain fatty acids and cholesterol by providing the mitochondrial enzyme cofactor adenosylcobalamin. Buildup of odd-chain fatty acids may cause demyelination.
- B12 and folate support the immune response to various infectious agents (oral or systemic). Adequate B12 and folate statuses are required for the proper proliferation of immune cells.