INFORMATION IS FOR PROFESSIONAL USE ONLY.
Educational information only. Not intended as a replacement for medical advice that is based on individual circumstances.
Q-Evail™ is a bioavailable proprietary CoQ10 formulation in a softgel format from Designs for Health.
Q-Evail™ offers 100mg of highly bioavailable ubiquinone coenzyme (CoQ10) in easy-to-swallow softgels. It is manufactured via a new, proprietary emulsification process that uses all-natural ingredients, including vitamin E, medium chain triglycerides (MCT) and lecithin that is free of polysorbates, castor oil, and polyoxyethylated chemicals. Superior bioavailability has been demonstrated in an in-house human clinical trial, showing this material to be up to eight times more bioavailable than crystalline CoQ10 powder.
Coenzyme Q10 is a fat-soluble, high molecular weight compound produced by
the body for the basic functioning of cells. It is synthesised endogenously on a
branch of the mevalonate pathway, which also produces cholesterol. CoQ10 plays
a central role in cellular energy metabolism that produces adenosine triphosphate
(ATP), the energy currency for muscle contraction and other cellular processes.
Organs with high energy demands, such as the heart and liver, have the highest
concentrations of CoQ10.
CoQ10 is recognised for its significant role in the electron transport chain as well as being one of the body's most vital antioxidants. It is found in the mitochondria, the energy-producing center or “powerhouse” of the cell. In addition to being produced in the body, CoQ10 can also be obtained in small amounts through certain dietary sources, such as fish (salmon and tuna) and organ meats (heart, liver and kidney). These amounts (internal and dietary), however, may often be inadequate to meet the body’s demands. Additionally, age and various illnesses, as well as the use of various medical classes, increase the need for this valuable nutrient. Thus, as is the case with many vitamins and minerals, supplemental amounts of CoQ10 may be beneficial for specific health conditions and may help limit oxidative damage.
Q-Evail™ offers 100mg of highly bioavailable ubiquinone coenzyme (CoQ10) in easy-to-swallow softgels. It is manufactured utilising the Designs for Health Evail™ process, which overcomes the poor absorption of crystalline/powdered CoQ10 formulas.
The absorption of the DFH Q-Evail™ softgel relative to DFH Q-Avail™ softgel was determined during a randomised crossover study with six healthy participants in August 2014. Blood samples were collected at baseline and at 2, 4 and 8 hours after oral ingestion of a single dose of 100 mg ubiquinone following an overnight fast on an empty stomach. CoQ10 levels in plasma were assayed by a national clinical testing laboratory.
The changes in plasma CoQ10 concentrations from baseline following oral ingestion of the formulations were determined and plotted as mean plasma CoQ10 concentration-time curves. Ingestion of DFH Q-Evail™ resulted in a higher increase in plasma CoQ10 above baseline.The area under the plasma CoQ10 concentration time-curves (AUCs) were calculated and relative absorptions between formulations were determined by dividing the AUC value of Q-Evail™ by that of Q-Avail™ for each subject (as shown in Figure opposite).
The in-house bioavailability study showed that CoQ10 in Q-Evail™ was up to 390% more absorbed than Q-Avail™.
Other products in the Evail™ Series:
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.