Laboratory Diagnostics

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PULS Cardiac Test


The PULS (Protein Unstable Lesion Signature) Cardiac Test by Cleveland Heart Lab measures key clinical risk factors including age, sex, diabetic status, family history of heart attack, and distinct protein biomarkers. These markers are associated with the biological pathways underlying cardiac lesion formation, progression and rupture. This refined methodology of cardiac risk assessment provides an improved calculation of a patient’s near-term (5 year) risk for a heart attack.

An Elevated PULS Cardiac Test May Identify:

  • Coronary heart disease development
  • Presence of unstable/vulnerable arterial plaque
  • Increased near-trm risk of a heart attack

Clinical Use: The PULS Cardiac Test may be performed on individuals at intermediate risk with one or more risk factors for coronary heart disease.

Clinical Significance: Cardiac risk assessments are used to identify the likelihood of a future cardiac event. The PULS Cardiac Test enhances risk assessment by evaluating clinical risk factors as well as 7 unique protein biomarkers associated with atherosclerotic disease progression and plaque vulnerability. PULS has demonstrated accuracy in predicting risk for cardiac events and was validated in the Multi-Ethnic Study of Atherosclerosis (MESA).1


1Cross DS et al. Curr Med Res Opin. 2012; 28: 1819-1830.

Sample Type
Turnaround time
8-10 working days
Additional Information / Instructions

More Information on the PULS Test.

Sample Reports / Downloads