Laboratory Diagnostics

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Metagenomics Stool Analysis

The metagenomics procedure to analyze bacterial populations in a stool sample is a state the art procedure based on 16s PCR amplification followed by high-throughput sequencing. It provides an comprehensive overview of all bacterial species, including those that could previously not be analyzed by traditional culture techniques.

The intestinal microflora can be considered as a postnatally acquired organ, composed of a large diversity of bacterial cells, that performs different functions for the host. The microflora plays a significant role in gut maturation, gut integrity, prevention of pathogenic and opportunistic bacterial colonization and modulates the immune system. It is also involved in vitamin synthesis, production of short chain fatty acids, metabolism of carcinogenic substances.

Although the intestinal flora is quite stable over time, a number of factors can disturb the normal balance leading to intestinal dysbiosis. Intestinal microflora can be altered by immune mechanisms of the host, redox state, adrenal function, intestinal pH, diet, aging, drugs, exogenous organisms, emotional stress. Intestinal dybiosis is seen in a number of chronic diseases such as Crohn's disease, IBS, CFS and may be associated with atopy and developmental disorders such as autism and ADHD.

Sample Type
Turnaround time
20-30 working days
Additional Information / Instructions
Sample Reports / Downloads