Laboratory Diagnostics

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Fertility Profile


Why Test?
Many women become pregnant easily, but for others this may require some assistance. ZRT’s Fertility Profile can help if you:

    • Have hormonal symptoms
      Have been trying to conceive for more than six months
      Are in your mid 30's or older
      Have had difficulty sustaining pregnancy in the past
      Know infertility runs in your family
      Want to assess your fertility status
Patients can collect their samples conveniently and at the appropriate cycle times with minimal disruption to their lives and busy work schedules. Sampling is done on days 3 and 21 of the menstrual cycle. The day 3 sample is optimal for assessment of ovarian reserves with the FSH and LH tests, while the other hormones are measured mid-luteally (day 21 commonly), when the level of hormones should be optimal for a successful pregnancy.


Blood Spot:

  • Estradiol (E2)
  • Progesterone (Pg)
  • Testosterone (T)
  • Sex Hormone Binding Globulin (SHBG)
  • DHEA-S (DS)
  • Thyroid Stimulating Hormone (TSH)
  • Free Triiodothyronine (fT3)
  • Free Thryoxine (fT4)
  • Thyroid Peroxidase Antibody (TPOab)
  • Follicle Stimulating Hormone (FSH)
  • Luteinizing Hormone (LH)


  •  Diurnal Cortisol (CX4)
Sample Type
Blood spot, Saliva
Turnaround time
5-7 working days
Additional Information / Instructions
Common hormone-related causes of female infertility:

Low Progesterone
Progesterone produced by the ovaries during the second half of the menstrual cycle is essential for preparing the uterus for implantation of the fertilized egg. In some patients, ovulation and fertilization of the egg may occur normally but progesterone is not produced in sufficient amounts to sustain pregnancy.

Thyroid Disorders
Low levels of the thyroid hormones fT3 and fT4 may prevent ovulation, which can be indicated by no periods or irregular cycles. Autoimmune thyroid issues, resulting in elevated levels of antibodies to the thyroid gland can increase the risk of miscarriages.

PCOS (Polycystic Ovary Syndrome)
PCOS affects between 6% and 15% of women during their reproductive years. PCOS is a common cause of ovulation problems, weight issues, and miscarriages. Once PCOS is recognized and treated, many women are able to become pregnant.

Low Egg Reserve
Declining egg production is the primary reason for the age-related decline in fertility. A low egg reserve can also be caused by premature ovarian failure.


Stress affects ovulation due to its effect on the endocrine system. High cortisol can inhibit ovulation, where low cortisol can affect the immune changes necessary for implantation to occur. Stress may also lead to the development of endometriosis, which is found in more than 50% of women with unexplained infertility.

Read more about the hormones tested in the ZRT Fertility Profile



Sample Reports / Downloads