C3a C4a Serum Profile
C4a serum level
C4a is an anaphylatoxin generated by cleavage of the complement component 4 (C4) upon activation of the component system. C4a increase causes local inflammatory response and symptoms of hypersensitivity. C4a levels are elevated following exercise in CFS patients. An US study had reported that elevated complement C4a was an early marker for Lyme disease in tick-bitten patients.
C3a serum level
C3a is one of the proteins formed by the cleavage of complement component 3. C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large role in the immune response.