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Clinical Significance of 5a-Reductase Activity
5a-Reductase (5AR) is the enzyme that catalyzes the conversion of (among others):
Finasteride® and Dutasteride®
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13 MHRA drug safety advice: Finasteride and potential risk of male breast cancer. http://www.nelm.nhs.uk/en/NeLM-Area/Evidence/Patient-Safety/MHRA-drug-safety-advice-Finasteride-and-potential-risk-of-male-breast-cancer/ Updated December 4, 2009. Accessed January 4, 2010.
14 Swedish package insert for Propecia 1mg. http://www.lakemedelsverket.se/SPC_PIL/Pdf/humpil/Propecia%201%20mg%20tablet.pdf. Accessed January 4, 2010.
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21 Kjellmen A, et al. Dihydrotestosterone Levels and Survival in Screening-Detected Prostate Cancer: A 15-yr Follow-up Study. European Urology. 2008. Jan;53(1):106-11. Epub 2007 Apr 26.
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23 Weihua, Z., R. Lathe, et al. An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci USA. 2002;99(21): 13589-94.
24 Dondi, D., M. Piccolella, et al. Estrogen receptor beta and the progression of prostate cancer: role of 5alpha-androstane-3beta,17beta-diol. Endocr Relat Cancer. 2010;17(3): 731-42.
25 Guerini, V., D. Sau, et al. The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype. Cancer Res. 2005;65(12): 5445-53.
26 Oliveira, A. G., P. H. Coelho, et al. 5alpha-Androstane-3beta,17beta-diol (3beta-diol), an estrogenic metabolite of 5alpha-dihydrotestosterone, is a potent modulator of estrogen receptor ERbeta expression in the ventral prostrate of adult rats. Steroids. 2007;72(14): 914-22.
27 Handa, R. J., T. R. Pak, et al. An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol. Horm Behav. 2008;53(5): 741-52.
28 Handa, R. J., M. J. Weiser, et al. A role for the androgen metabolite, 5alpha-androstane-3beta,17beta-diol, in modulating oestrogen receptor beta-mediated regulation of hormonal stress reactivity. J Neuroendocrinol. 2009;21(4): 351-8.
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30 Parsons, J. K., K. Palazzi-Churas, et al. Prospective study of serum dihydrotestosterone and subsequent risk of benign prostatic hyperplasia in community dwelling men: the Rancho Bernardo Study. J Urol. 2010;184(3): 1040-4.
31 Gustafsson, O., U. Norming, et al. Dihydrotestosterone and testosterone levels in men screened for prostate cancer: a study of a randomized population.” Br J Urol. 1996;77(3): 433-40.